Vicia faba Lectin (VFA)

Vicia faba Lectin (VFA)


Vicia faba agglutinin (VFA) is isolated from fava beans and is purified by affinity chromatography. It is a glycoprotein with a molecular weight of 52,000, and is a tetramer composed of two dissimilar subunits. This lectin is a weak, non-specific hemagglutinin that has a carbohydrate specificity for mannose and glucose, and elutes with the sugar mannose. VFA is mitogenic for human and murine lymphocytes.
The lyophilized preparation of VFA forms insoluble aggregates between pH 5 and 10. All preparations of VFA contain various fragments and polymers of the two subunits. When stored at a pH lower than 5, the lectin does not form aggregates, which may be explained by the lectins reactivity with mannose.
VFA can increase morphological differentiation and thus diminish the malignant phenotype of colorectal cancer cells. VFA appears to be the only known non-toxic dietary lectin, other than ABL, with inhibitory effects on proliferation. This lectin and other mannose binding plant lectins may contribute to protection from colorectal cancer by vegetables through effects on tumor development.

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Cat#
Description
Cond.
Price Bef. VAT
L1204-10
 10mg 
L1204-2
 2mg 
V2121-96-1mg
 1mg 
V2121-96-2mg
 2mg 
518912-1mg
 1mg 
518915-1mg
 1mg 
V2121-96H-1mg
 1mg 
518920-2mg
 2mg 
518916-1mg
 1mg 
518919-1mg
 1mg 
V2121-96F-1mg
 1mg 
V2121-96M-1mg
 1mg 
518913-2mg
 2mg 
V2121-96L-1mg
 1mg 
V2121-96G-1ml
 1ml 
V2121-96G2-1ml
 1ml