Biomimesys® Brain : A natural hydroscaffold for 3D culture of neuronal cells
To better mimic the tissue microenvironment and to permit long term culture of neuronal cells
BIOMIMESYS® hydroscaffold 3D is the only ready to use hydroscaffold based on Hyaluronic Acid (HA) and extracellular matrix compound.
BIOMIMESYS® Brain is physiological
BIOMIMESYS® Brain is a unique ready to use biofunctionalized Hyaluronic Acid (HA) hydroscaffold suitable for neuronal cell culture. BIOMIMESYS® Brain is created by double crosslinking reaction of components of brain extracellular matrix: collagen IV, cell binding domain of fibronectin (RGDS), cationic bioplolymer and Hyaluronic acid.
With the aim of better mimicking the structural properties of brain, BIOMIMESYS® Brain is made up of 80% empty volume and with a high porosity around 170µm.
BIOMIMESYS® Brain provides also enough space for gas, medium and nutrients flow circulation of fragile neuronal cell with cell-cell and cells-matrix interactions, along with a mechanical support required for an easy handling of hydroscaffold.
Spheroid dopaminergic neurons (Luhmes) in BIOMIMESYS® Brain :
Blue: nucleus, green: b3-tubulin
BIOMIMESYS® Brain is ready-to-use
- Available in a ready-to-use format (96 well plates) it enables the culture of neuronal cells under physiological conditions that are representative of the tissue microenvironment.
- Cells are simply seeded on top of the hydroscaffold and placed in the incubator
- The media can be refreshed easily by pipetting.
BIOMIMESYS® is compatible with all anatycal technologies
TRANSPARENT : Microscopy and plate reader
POROUS : PCR, Western Blot, ELISA
BIODEGRADABLE : Flow cytometry
SOLID : Histology and in vivo transplantation