FISH probes : discover our new products
New FISH probes for diagnosis
Cell which shows two green/orange/blue fusion signals (NTRK3) and one green/orange fusion signal (NTRK1).
NTRK1 rearrangement is indicated by one isolated orange signal, not co-localizing with a blue signal
The FlexISH ® NTRK1/NTRK3 DistinguISHTM Probe is designed to detect rearrangements affecting the chromosomal region 1q23.1 and 15q25.3 harboring the NTRK1 and NTRK3 gene region, respectively. The treatment of patients with NTRK fusion-positive cancers with a NTRK inhibitor is associated with high response rates, regardless of NTRK gene, fusion partner, and tumor type.
RET Dual Color Break Apart FISH Probe hybridized to normal interphase cells as indicated by two orange/green fusion signals per nucleus.
The ZytoMation® RET Dual Color Break Apart FISH Probe is designed to detect translocations involving the chromosomal region 10q11.21 harboring the RET gene. RET encodes a tyrosine kinase receptor. RET translocations are responsible for 1-2% of non-squamous NSCLCs. Similarly to ALK and ROS1, they are more characteristic for young non-smokers and females.
IGH Dual Color Break Apart FISH Probe hybridized to normal interphase cells as indicated by two orange/green fusion signals per nucleus
The ZytoMation® IGH Dual Color Break Apart FISH Probe is designed to detect translocations involving the chromosomal region 14q32.33 harboring the IGH locus. Rearrangements involving the IGH gene locus are considered to be cytogenetic hallmarks for non-Hodgkin lymphoma. IGH locus rearrangements have been identified in about 50% of NHLs and are associated with specific subtypes of NHLs.
The ZytoMation® Probes are designed for fully automated application on the Leica Bond stainers:
- Leica BOND"-III
- Leica BOND"-MAX
- Leica BOND" RXm (RUO)
Medical devices for in vitro diagnosis. Read the operating instructions carefully.